• Nonivamide: TRPV1 Agonist as an Anti-Proliferative Agent ...

  2025-09-23

  Explore the multifaceted applications of Nonivamide, a potent capsaicin analog, as a TRPV1 receptor agonist in cancer and neuroimmune research. This article delves into its mechanisms of cancer cell growth inhibition, apoptosis induction via mitochondrial pathways, and its emerging role in TRPV1-mediated anti-inflammatory signaling.

• Nonivamide: TRPV1 Agonism and Apoptosis Pathways in Cance...

  2025-09-22

  This article examines Nonivamide (Capsaicin Analog) as a potent TRPV1 receptor agonist, focusing on its anti-proliferative mechanisms in cancer research and its role in apoptosis induction via mitochondrial pathways. Novel perspectives on Nonivamide-mediated TRPV1 signaling and its translational research potential are presented.

• Nonivamide: A TRPV1 Agonist for Cancer and Inflammation R...

  2025-09-19

  Nonivamide, a selective TRPV1 receptor agonist and capsaicin analog, demonstrates promising anti-proliferative and anti-inflammatory properties for advanced cancer and immunology research. This article explores its mechanisms, experimental uses, and

• Nonivamide: Mechanistic Insights into TRPV1-Mediated Anti...

  2025-09-18

  This article explores Nonivamide, a capsaicin analog and TRPV1 receptor agonist, highlighting its unique dual roles in apoptosis induction via mitochondrial pathways and modulation of inflammatory responses. We provide a rigorous analysis of recent mechanistic findings, emphasizing its utility as an anti-proliferative agent for cancer research and a tool for dissecting TRPV1-mediated calcium signaling.

• A highly attenuated B pertussis strain named BPZE has

  2025-03-03

  

  A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with

• Interestingly a homolog of C elegans acr is

  2025-03-03

  

  Interestingly, a homolog of C. elegans acr-23 is present in the A. suum Benzoylhypaconitine receptor (Jex et al., 2011). However, A. suum is not susceptible to monepantel treatment in vivo (Tritten et al., 2011). Our research seeks to advance knowledge on the mode of action of monepantel on nAChRs f

• The reaction of LOX with

  2025-03-03

  

  The reaction of 5-LOX with unlabeled AA generated products from hydrogen abstraction at C7 (95% 5-HETE) with minor products derived from abstraction at C10 (5% 8-HETE). With 7,7--AA the selectivity remained skewed towards C7 hydrogen abstraction (59%) compared to C10 hydrogen abstraction products (4

• br The Molecular Machinery of Autophagy and Regulation by

  2025-03-03

  

  The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to

• glyoxylic acid hair treatment Aurora A overexpression is als

  2025-03-03

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer glyoxylic acid hair treatment [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene

• br Author contributions br Acknowledgments

  2025-03-01

  

  Author contributions Acknowledgments TJC, KW, and VG are supported by awards made to MJN: a Consolidator Grant from the European Research Council under Grant no. 311336; a University Research Fellowship from the Royal Society, and a Career Development Award from the Human Frontiers Science Pro

• On the contrary Birrel and colleagues

  2025-03-01

  

  On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 meclofenamate growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It is worth

• Although our sample size is

  2025-03-01

  

  Although our sample size is not enough to conclude that there is no great genetic variation of the AR gene in most New World monkeys, it would be reasonable to state that the microsatellite region in the exon 1 of the androgen receptor gene of New World monkeys (platyrrhine) is relatively shorter th

• SC75741 br Selective Androgen Receptor Modulators SARMs The

  2025-03-01

  

  Selective Androgen Receptor Modulators (SARMs) The AR and its endogenous ligands, androgens, are important for development and maintenance of muscle and bone, secondary sexual organs, and development of other tissues (Mooradian et al., 1987). Although androgens are important for normal developmen

• Through systematic deletion of AhR in specific cell

  2025-03-01

  

  Through systematic paroxetine hydrochloride of AhR in specific cell types, Di Meglio et al. (2014) revealed that AhR in keratinocytes and fibroblasts are key to the exacerbated psoriatic phenotype induced by IMQ in AhR-deficient mice. This emphasizes the crosstalk between keratinocytes and the immun

• br ABCA mRNA expression is elevated in

  2025-03-01

  

  ABCA2 mRNA expression is elevated in Niemann-Pick type C and familial hypercholesterolemia fibroblasts Niemann-Pick Type C disease is a neurological disorder of adolescents due to autosomal-recessive mutations in either one or both Niemann-Pick-2 (NPC2) and NPC1 genes, which, like ABCA2, are loca

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