• Finally our results suggest that R may at least

  2020-03-24

  

  Finally, our results suggest that σ2R may, at least partially, mediate the hunger-suppressive action of amphetamine by interacting with orexigenic receptors in CRF2R-OX1R heteromer contexts. Despite extensive evidence supporting the formation of GPCR oligomers in heterologous systems, the lack of ap

• carbenoxolone Hymenialdisine the most potent inhibitor

  2020-03-24

  

  Hymenialdisine, the most potent inhibitor of parasite TgCK1 enzymes in vitro has no whole cell anti-parasitic activity (Table 2). Like purvalanol B however, this carbenoxolone also displays poor activity against target enzymes in cultured cells. For example, in vitro IC50 values for inhibition of CD

• Recent studies have shown that some CLC genes participate in

  2020-03-24

  

  Recent studies have shown that some CLC genes participate in plant salt tolerance and have speculated that they function by mediating Cl− transport across the tonoplast. For instance, AtCLCc, a vacuolar anion transporter, is shown to be involved in the regulation of stomatal movement and to contribu

• br Acknowledgements br This work was supported by grants

  2020-03-24

  

  Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (Grant No.: 30260088) and the prophase research for National “973” Project of China (Grant No.: 2007CB116203). The DNA sequences of Hbvp1 and the Hbvp1 promoter were deposited in GenBank, an

• In the present study we investigated the deeper

  2020-03-24

  

  In the present study, we investigated the deeper role of eNOS in the pathogenesis of nasal polyps and analyzed the influence of 1,8-cineol on nasal polyp gene and protein expression of eNOS in vitro. Different studies dealt with the localization and expression of eNOS in nasal polyps and nasal mucos

• Because aspirin and ibuprofen are

  2020-03-24

  

  Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, mlkl and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated with aspirin who

• Palliative surgeries for refractory epilepsy include vagus n

  2020-03-24

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• However the Moon is not the only possible source for

  2020-03-24

  

  However, the Moon is not the only possible source for space resources. Asteroids, in particular near-Earth asteroids (NEAs), can provide an alternative source for propellant and other materials, sometimes at lower cost. There are an expected 4000 NEAs that require less propellant (delta-V) per trip

• Altiratinib receptor Spinal cord injury leads to an extensiv

  2020-03-24

  

  Spinal cord injury leads to an extensive inflammatory cascade on spinal cord and the release of pro-inflammatory cytokines can sensitize neurons, activating signaling pathways that will result in thermal and mechanical hypersensitivity [39]. In this regard, Guo and collaborators (2014) demonstrated

• br Results To understand how Rad functions

  2020-03-23

  

  Results To understand how Rad53 functions to maintain replisome integrity, we first analyzed newly synthesized leading- and lagging-strand DNA in wild-type (WT) and rad53-1 mutant cells using BrdU-IP-ssSeq, a method that detects synthesis of both leading and lagging strands (Yu et al., 2014). Bri

• It has been shown that DAPK

  2020-03-23

  

  It has been shown that DAPK induces cell death through an increase in DAPK catalytic activity and subsequent phosphorylation of target proteins (Shang et al., 2005, Yamamoto et al., 2002), but its multidomain structure enables also a close physical interaction with other proteins (Bialik and Kimchi,

• The sex dimorphic expression of mouse

  2020-03-23

  

  The sex-dimorphic clemastine mg of mouse CYP3A is partially due to sex-dimorphic plasma GH profile which is a decisive factor in the regulation of sexspecific CYP isoforms [14]. Nevertheless, in our study we did not observe any changes in plasma GH levels in either mouse sex with a selective ablati

• br Materials and Methods br Results br Discussion

  2020-03-23

  

  Materials and Methods Results Discussion HSCs have been identified as major collagen-producing CU CPT 22 in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulatory

• Our previous studies have shown that in a

  2020-03-21

  

  Our previous studies have shown that in a preimplantation mouse embryo the proportion of inner to outer cells (i.e. precursors of ICM and TE, respectively) is regulated by a different frequency of differentiative cell divisions at the 8- and 16-cell stages. Low number of inner blastomeres generated

• br Introduction Lung cancer is the leading cause

  2020-03-21

  

  Introduction Lung cancer is the leading cause of cancer-related death worldwide, accounting for more than 1.5 million deaths in 2012. Non–small-cell lung cancers represent approximately 85% of lung neoplasms; among these, squamous cell carcinomas (SCC) account for approximately 30% of cases. The

14331 records 853/956 page Previous Next First page 上5页 851852853854855 下5页 Last page