• br STAR Methods br Author Contributions br Acknowledgments T

  2020-06-03

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• Chlorothiazide mg In the current study cocaine

  2020-06-03

  

  In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,

• Cryptosporidium is a protist causing serious diarrhea in hum

  2020-06-03

  

  Cryptosporidium is a protist causing serious diarrhea in humans and other animals (Bouzid et al. 2013). In its mitosomes, the most reduced forms of mitochondria, it is assumed that the membrane potential is generated by a simple respiratory chain consisting of transhydrogenase, type II NADH dehydrog

• To understand the behavior of

  2020-06-02

  

  To understand the behavior of enzymes in ILs at a molecular level, it is first desirable to dissolve enzymes in the solvents. For soluble catalysts, there are many relatively simple spectroscopic and other techniques for obtaining accurate information at a molecular level. Parker et al. [9] reported

• In conclusion we have identified

  2020-06-02

  

  In conclusion, we have identified Ednra as a downstream direct target of Hoxa9 and Meis1. Upregulation of Ednra has a role in the progression of Hoxa9+Meis1-induced leukemia and targeting Ednra together with other chemotherapies may have therapeutic benefits for leukemia [30]. Ednra inhibitors in th

• In terms of its protease activity MME has a broad

  2020-06-02

  

  In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other adenosine deaminase of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade th

• br Proteases with special focus on cysteine

  2020-06-02

  

  Proteases with special focus on cysteine proteases Vaccination using cysteine proteases as antigens with special emphasis on DNA-vaccines Concluding remarks In spite of the great potential of DNA vaccines, the technology has not been as revolutionary as expected in higher mammals. In fish,

• The final test that was

  2020-06-02

  

  The final test that was performed was to determine whether the trigger points of the current limiters are stable across a wide temperature range. This test was performed within a thermal-vacuum chamber on each current limiter individually. All the current limiter trip currents were set to approximat

• Introduction Human cytomegalovirus CMV is

  2020-06-02

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

• MdHCLB channels expressed in Xenopus oocytes produced curren

  2020-06-02

  

  MdHCLB channels expressed in Xenopus oocytes produced currents in response to HA and GABA (Fig. 1, Fig. 3). This is in agreement with the findings with Drosophila HCLB channels (Gisselmann et al., 2004). In the HA concentration-response curves, the effects of GABA were additive to those of HA only i

• Perturbations in cell cycle are known to

  2020-06-02

  

  Perturbations in Fesoterodine Fumarate are known to induce apoptosis. Our results show that a fraction of the DT40YB-1b+/− cells, in addition to becoming tetraploids, undergo apoptotic cell death. Similar observations linking polyploidy and apoptosis have been made in the past [23], [30], [31], [32

• Increased leukocyte trafficking and infiltration of

  2020-06-02

  

  Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg

• It has been reported that PGE

  2020-06-02

  

  It has been reported that PGE2 increases expression of the survivin mRNA (Baratelli et al. 2005) and promotes the stabilization of the survivin protein in some tumor MLCK inhibitor peptide 18 (Krysan et al. 2003). However, it is unclear whether PGE2 affects the expression of survivin mRNA or promot

• br Introduction Hydrogen sulfide H S and nitric oxide NO

  2020-06-02

  

  Introduction Hydrogen sulfide (H2S) and nitric oxide (NO) are important gasotransmitters in the cardiovascular system and instrumental to the fine control of vascular tone [1] and cellular function [2]. NO is synthesized from l-arginine by calmodulin-dependent endothelial nitric oxide synthase (e

• Although both DNA DSBs and DNA PK

  2020-06-02

  

  Although both DNA DSBs and DNA-PK activity increase with aging in skeletal muscle (Figure 1), we cannot conclude that aging-associated increase in DNA-PK activity is solely mediated by chromosomal breaks, as DNA-PK is also activated independently of chromosomal breaks by ROS (Li et al., 2014), which

14378 records 824/959 page Previous Next First page 上5页 821822823824825 下5页 Last page