• We and others have previously found that

  2020-08-05

  

  We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and Glutathione (GSH/

• Protection of DNA is a cancer preventive mechanism both

  2020-08-04

  

  Protection of DNA is a cancer preventive mechanism; both oxidative and alkylating damage to colonocytes are known effects of dietary carcinogens. Concerning the DNA protection experiments, two different DNA damaging agents, an oxidant (H2O2) and alkylating (MMS) agent, were used. Hydrogen peroxide i

• In our studies we found that

  2020-08-04

  

  In our studies, we found that the DHODH inhibitors increased the expressions of STAT6 and p65/NF-κB in sensitive breast cancer cells. These signalling molecules could interact directly with each other in vitro and in vivo by cooperatively binding to their associated DNA GTP-Binding Protein Fragment,

• br Acknowledgments Authors acknowledge financial support fro

  2020-08-04

  

  Acknowledgments Authors acknowledge financial support from the National Natural Science Foundation of China (31402274, 31172389), the Special Project of Marine Renewable Energy from the State Oceanic Administration (SHME2011SW02), China Postdoctoral Science Foundation (2014M551381) and Shanghai U

• However it is not clear whether CysLTs induce eosinophilic m

  2020-08-04

  

  However, it is not clear whether CysLTs induce eosinophilic migration in vitro. Nagy et al. reported that neither leukotriene C4 (LTC4) nor leukotriene D4 (LTD4) caused chemotaxis of eosinophils [5]. However, Spada et al. reported contradictory findings, showing that CysLTs elicit chemotactic activi

• The aim of the current project was

  2020-08-04

  

  The aim of the current project was to establish an E. coli based expression system to produce high amounts of recombinant Lys-C. Furthermore, the development of an optimized refolding process for Lys-C using the separately recombinant produced N-terminal pro-peptide of Lys-C in the refolding assay w

• The individuals described here experienced corneal vasculari

  2020-08-04

  

  The individuals described here experienced corneal vascularization in early adult life. DDR2 is able to both drive and prevent angiogenesis under different conditions.21, 22, 23 The primary effect seems to be angiogenesis stimulation, but a rebound effect or overcompensation can counterbalance this.

• The involvement of MDM in mechanisms

  2020-08-04

  

  The involvement of MDM2 in mechanisms underlying development of inflammatory autoimmune diseases is additionally supported by recent data showing that MDM2 promotes rheumatoid arthritis [33]. Here, collagen-induced arthritis mouse model was used to demonstrate that high MDM2 levels correlated with d

• Present study measured only baseline preirradiation levels o

  2020-08-04

  

  Present study measured only baseline (preirradiation) levels of PARP-1 and DNA-PK expression. Due to study design, changes in these proteins that might occur during radiotherapy cannot be described. However, previous in vitro study has shown that there is a radiation-induced increase in the activity

• br The important role of DNA PK in

  2020-08-04

  

  The important role of DNA-PK in metabolic gene regulation To meet the constant energy requirement in the face of highly variable food supply, mammals employ intricate and precise mechanisms for energy storage. When total energy intake is in excess of energy expenditure (such as after a meal), exc

• SmDHODH showed to catalyze the conversion of dihydroorotate

  2020-08-04

  

  SmDHODH showed to catalyze the conversion of dihydroorotate into orotate using quinone as Flufenamic acid acceptor following a ping-pong mechanism. Despite the overall resemblance to the human homologue enzyme, substitutions and differences in the conformational states adopted by HsDHODH and SmDHOD

• br Competing interests br Acknowledgements This work was sup

  2020-08-04

  

  Competing interests Acknowledgements This work was supported by a Grant-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (26304036), Japan. Introduction Cancer is a disease of dysregulated cell growth and metabolism-re

• It is somewhat interesting to find that AMPK

  2020-08-03

  

  It is somewhat interesting to find that AMPK activator metformin decreased the CPT1 expression in the setting of PA stimulation or HFD feeding. It is known that AMPK promotes phosphorylation of acetyl-CoA carboxylase and increase CPT1 activity, thus enhance FAO. We observed that metformin, DCA, mild

• Most of the research works

  2020-08-03

  

  Most of the research works in the field of thermodynamic modeling of gas hydrate phase equilibria have been performed through van der Waals-Platteeuw modeling approach since 1954 [[9], [10], [11], [12], [13]]. Chen and Guo [8,14], proposed an alternate statistical mechanics based hydrate model by pr

• CE ribotyping applied on a Czech C difficile

  2020-08-03

  

  CE-ribotyping applied on a Czech C. difficile isolate collection demonstrates its high discrimination capability and the results highlight the need to use a standardised protocol as well as a standardised CE-ribotyping profile library to gain inter-laboratory comparable data on clinically and/or epi

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