• To date very little is known about the GEFs

  2021-11-26

  

  To date, very little is known about the GEFs that regulate RhoA during amoeboid migration. GEF-H1, a RhoA GEF, is activated response to microtubule destabilization and promotes amoeboid migration (Eitaki, Yamamori, Meike, Yasui, & Inanami, 2012). Interestingly, the majority of Paclitaxel depleted o

• br Molecular mechanisms underpinning GSNOR

  2021-11-26

  

  Molecular mechanisms underpinning GSNOR1 function in the defence response Recently, Arabidopsis GSNOR1 has been shown to govern the extent of S-nitrosylation of two key regulatory proteins, Non-Expresser of Pathogenesis-Related Genes 1 (NPR1) and SA binding protein 3 (SABP3), which are integral t

• Mice lacking S nitrosoglutathione reductase GSNOR a

  2021-11-26

  

  Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro

• br Clinical development of anti NASH drug therapies The

  2021-11-25

  

  Clinical development of anti-NASH drug therapies The current understanding of NASH pathogenesis has led to broad efforts to target several features of the disease, alone or in combination, even in the absence of liver-guided therapies. Therefore, drug development in NASH is a rapidly changing fie

• Licofelone Elimination of the Q R

  2021-11-25

  

  Elimination of the Q234–R244 bridge significantly affected the protein Licofelone but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound zinc

• br A small conductance chloride channel

  2021-11-25

  

  A small conductance chloride channel (SCC) In addition to the above-described channels, a 5pS SCC has been encountered in electrophysiological recordings. This channel, exhibiting long periods of opening separated by long intervals of closing, showed the same characteristics as the SCC described

• There is increasing evidence that Cxs in astrocytes

  2021-11-25

  

  There is increasing evidence that Cxs in astrocytes may play a role in several models of brain pathologies. Interestingly their roles are at the moment more considered through their hemichannel function (Bennett et al., 2012; Bosch and Kielian, 2014; Davidson et al., 2013; Orellana et al., 2016; Kim

• Seizures in turn selectively modulate the expression of GalR

  2021-11-25

  

  Seizures, in turn, selectively modulate the Toyocamycin of GalR in the hippocampus. Thus, pilocarpine-induced SE led to a 30% downregulation of GalR2 without affecting GalR1 (personal communication with T. Bartfai, Scripps Research Institute). Therefore, despite the fact that GalR2 could have been

• Prior models suggest that the terminal ends of the

  2021-11-25

  

  Prior models suggest that the terminal ends of the endocrine FGFs individually determine FGFR and KLB recognition, with little or no cross-talk. Our results confirm that short C-terminal sequences are necessary and sufficient to bind KLB and, supportive of a common mechanism, the underlying structur

• br Declarations of interest br

  2021-11-25

  

  Declarations of interest Founding information This work was partially supported by the New Energy and Industrial Technology Development Organization (NEDO) Japan [grant number P03043]; and Grants-in-Aid for Scientific Research [grant number 16H00738 to H.M.] from the Japan Society for the Prom

• Thus from this preliminary study a working model of

  2021-11-25

  

  Thus from this preliminary study, a working model of HIV-1 integrase was developed from which a selective inhibitor of the strand-transfer reaction displaying whole-cell activity and negligible cytotoxicity was produced. Compound 9 provides a promising scaffold for further elaboration, and current i

• The neurotransmitter histamine plays a key role in the

  2021-11-25

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in Swainsonine histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease and d

• br Hedgehog pathway The Hedgehog pathway Fig

  2021-11-25

  

  Hedgehog pathway The Hedgehog pathway (Fig. 1) derives its name from Hh gene mutant Drosophila, which presents a spiked phenotype resembling the animal “hedgehog” [13]. The Hh proteins control embryonic development in vertebrates, where the signaling mechanisms mediated by the proteins are multip

• br Results br Discussion To further evaluate

  2021-11-25

  

  Results Discussion To further evaluate the extent of H3T3A and H3T3D roles in the segregation of sister chromatids enriched with different populations of H3 during mitosis (Figure 1B, step two), we modeled all possible segregation patterns in male GSCs and compared these estimates to our exper

• Annexin A ANXA a member of annexin superfamily is

  2021-11-25

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

14043 records 506/937 page Previous Next First page 上5页 506507508509510 下5页 Last page