• It has been suggested that MAPK Huang et al Uddman

  2022-03-09

  

  It has been suggested that MAPK (Huang et al., 2013, Uddman et al., 2003, Xu et al., 2008) signaling pathway is involved in the transcriptional upregulation of ETB receptor. The present study demonstrated that treatment with CsA increased phosphorylation of ERK1/2 and p38. Inhibition of ERK1/2 and p

• Recent studies in our laboratory

  2022-03-08

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

• As an inflammatory mediator histamine

  2022-03-08

  

  As an inflammatory mediator, histamine plays a pivotal role in nociceptive processes in both the central and peripheral nervous systems (Gemkow et al., 2009; Hough & Rice, 2011; Tiligada et al., 2009). In this respect, the participation of H3Rs in modulating pain, especially neuropathic pain, has at

• Although we showed that RBL H Sc cells took

  2022-03-08

  

  Although we showed that RBL-2H3 Sc98 rosmarinic acid receptor took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family,

• Work is presently underway to unveil mechanisms whereby SAHA

  2022-03-08

  

  Work is presently underway to unveil mechanisms whereby SAHA-dependent restoration of cardiomyocyte autophagic flux is protective. Another interesting question pertains to mechanisms whereby class I and class II HDAC inhibitors induce autophagy. It has been demonstrated that TSA reduces transverse a

• br Materials and methods br Results

  2022-03-08

  

  Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data

• The balance and composition of

  2022-03-08

  

  The balance and composition of the gut microflora can be altered by the use of antibiotics or by colonization of the intestine by pathogens. This change may also induce, or be induced by, modifications in the body’s immune response, ultimately leading to disease. Thus, when intestinal homeostasis is

• Immunohistochemical analysis of sheep skin sections showed t

  2022-03-08

  

  Immunohistochemical analysis of sheep skin sections showed that sGC prtotein is expressed in the hair follicles with different location and abundance between white and black sheep skin (Fig. 6). In white sheep skin, Strong sGC positive signal was detected in the upper hair dermal papilla but no pos

• Like tBHQ and DEM treatment

  2022-03-08

  

  Like tBHQ and DEM, treatment of Keap1+/+ MEFs with SFN increased the abundance of Hmox1 and Nqo1 mRNA, and this was blunted by LY294002 and MK-2206 (Figure 2C). However, unlike the situation with tBHQ and DEM, treatment of Keap1−/− MEFs with SFN did not increase further the elevated basal levels of

• br Results and discussion br

  2022-03-08

  

  Results and discussion Conclusions Introduction There is no effective treatment for HIV-associated neurocognitive disorder (HAND) which affects about half of the over 36 million people infected (Saylor et al., 2016). HIV can remain in the Propylthiouracil during combination antiretroviral

• Retigabine dihydrochloride GlxI is a member of the superfami

  2022-03-08

  

  GlxI is a member of the βαβββ superfamily of proteins, consisting of fosfomycin resistance protein (FosA), methylmalonyl-CoA epimerase (MMCE), extradiol dioxygenase (DIOX), mitomycin C resistance protein (MRP) and bleomycin resistance protein (BRP) [29], [30], [31]. These proteins are believed to ha

• In insects structural cuticular proteins CPs play

  2022-03-08

  

  In insects, structural cuticular proteins (CPs) play important roles in determining the diverse physical properties of the cuticle, depending on developmental stages, as well as different body regions, as a result of interactions with other CPs and the structural biopolymer chitin [4]. Many studies

• In vitro studies have shown that some antidepressant drugs b

  2022-03-08

  

  In vitro studies have shown that some antidepressant drugs bind to NMDA receptors and inhibit the binding of NMDA receptor ligands [18]. Similarly, several research teams have reported that tricyclic antidepressants can modulate the release and/or uptake of glutamate [19]. In this study, we found th

• Here we reported series of carbohydrate modified compounds c

  2022-03-08

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of β-Sitosterol and their polyol structures give them many unique biological properties as we have described earlier. More

• br Acknowledgements This research was funded by Ministry

  2022-03-08

  

  Acknowledgements This research was funded by Ministry of Education Malaysia (MOE), and supported by the Department of Nutrition, Exercise & Sports, Department of Drug Design, University of Copenhagen, Denmark and Universiti Malaysia Pahang (UMP), Malaysia. HPLC equipment used for high-resolution

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