• Introduction An association of elevated branched chain amino

  2023-10-16

  

  Introduction An association of elevated branched-chain topotecan (BCAA—Leu, Val, Ile) with obesity and insulin resistance was first reported nearly 50 years ago (Felig et al., 1969). With the advent of metabolomics technologies, it has since become apparent that the association of BCAA and related

• Transient transfection with ATR kinase dead D

  2023-10-16

  

  Transient transfection with ATR kinase-dead (D2475→A) [30] and ATM kinase-dead (D2870→Ala and N2875→K) [31] constructs was performed using Fugene 6 (Roche Applied Science, Indianapolis). Three microliters of fugene 6+1μg plasmid was used in transfections using 6-well plates at 2×105 cells/well and

• APJ receptors have a amino acid sequence with a

  2023-10-13

  

  APJ receptors have a 380 amino Cap Firefly Luciferase mRNA sequence with a characteristic G-protein structure, including seven transmembrane domains and post-translation modification sites for phosphorylation, palmitoylation and glycosylation along with association sites for β-arrestin (O'Dowd et a

• A key function of the

  2023-10-13

  

  A key function of the reference AFST would be to detect fungal resistance, i.e. to determine which antifungal agents are likely to be clinically inactive [2]. To this end, the epidemiological cut-off value, defined as ‘the upper end of the wild-type (WT) or beginning of the non-wild-type (NWT) MIC d

• br Conclusions br Acknowledgments br Introduction

  2023-10-13

  

  Conclusions Acknowledgments Introduction The surface water bodies are affected by effluents containing pollutants from wastewater treatment plants, storm water overflows and run-off from non-point sources like agricultural land and urban city surfaces. This relates to land-based sources occ

• br Acknowledgments This work was supported by grants from th

  2023-10-13

  

  Acknowledgments This work was supported by grants from the “Agence Nationale de la Recherche” ANR-09-CESA-006 program, the Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (Anses, Project n° 2012-2-077) and the Interdisciplinary Program “Longévité et Viei

• br Acknowledgments and Disclosures br Introduction Over

  2023-10-13

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1], A

• Linagliptin is a recently approved dipeptidyl peptidase DPP

  2023-10-13

  

  Linagliptin is a recently approved dipeptidyl peptidase-4 (DPP-4) inhibitor and widely considered as first-line treatment for patients with type 2 diabetes. DPP-4 is responsible for the inactivation of incretin hormones, such as glucagon-like peptide 1 (GLP-1). GLP-1 is released by the intestine aft

• Accumulating evidence indicates that experience dependent al

  2023-10-13

  

  Accumulating evidence indicates that experience-dependent alterations in glutamate transmission in the NAc, such as those produced by repeated exposure to cocaine, involve alterations in postsynaptic signaling mediated by AMPA-type receptors (Pierce and Wolf, 2013, Wolf and Ferrario, 2010). In the N

• A straightforward synthetic pathway was adopted to

  2023-10-13

  

  A straightforward synthetic pathway was adopted to synthesize the target compounds as outlined in . The starting chloromethylquinazolinones (–) were synthesized from anthranilic Bisindolylmaleimide IV australia in two steps following reported procedures., , , The first step involves chloroacetylatio

• br Conclusion br Conflict of interest

  2023-10-13

  

  Conclusion Conflict of interest Acknowledgments We thank Nancy Kerkvliet for helpful advice. The research in the lab of CE and THS is supported by the Deutsche Forschungsgemeinschaft (grants ES103/7-1 and 9-1, HA7346/2-1). We apologize to all authors whose work could not be cited due to lim

• br Material and methods br Results br Discussion GRK

  2023-10-13

  

  Material and methods Results Discussion GRK2 activity has increasingly been shown to contribute to the progression of numerous diseases and organ dysfunction [5], [6]. For instance, a large body of work over the last two decades has identified GRK2 as a major regulator of cardiac dysfunctio

• APPL was the first adaptor protein identified that interacts

  2023-10-13

  

  APPL1 was the first adaptor protein identified that interacts directly with adiponectin receptors [18]. A two-hybrid study by Dong and colleagues revealed that the C-terminal extracellular domain of AdipoR1 interacts with adiponectin, whereas the N-terminal cytoplasmic domain of AdipoR1 interacts wi

• br Functional consequences of ADK regulation on astrocyte fu

  2023-10-13

  

  Functional consequences of ADK regulation on astrocyte function As outlined above (see introduction), ADK critically regulates the extracellular adenosine levels in BX-912 (Boison, 2006, Etherington et al., 2009). Changes in the levels of adenosine, as a result of the regulation of ADK expressio

• Oxidative stress has recently been reported as one of

  2023-10-13

  

  Oxidative stress has recently been reported as one of the important mechanisms of toxic effect of Cd2+[43]. The mechanism of Cd2+-induced oxidative stress involves an imbalance between generation and removal of ROS in tissues and cellular components, causing damage to membranes, DNA, and proteins [4

13985 records 225/933 page Previous Next First page 上5页 221222223224225 下5页 Last page