• Aurora kinases were initially identified as protein kinases

  2023-10-31

  

  Aurora kinases were initially identified as protein kinases essential for error-free chromosome segregation during mitosis and meiosis. Aurora A appears to control premetaphase events, such as bipolar spindle assembly 3, 4, with Aurora B and C directing metaphase and postmetaphase events, including

• br Concluding Remarks and Future

  2023-10-30

  

  Concluding Remarks and Future Perspectives Herein, we have highlighted our current understanding of the role of the LKB1-AMPK pathway and its related kinases in β cell biology. β cell-specific genetic models have been particularly useful in delineating precise roles for individual family members

• diltiazem hcl br Acknowledgements br Introduction Microbial

  2023-10-30

  

  Acknowledgements Introduction Microbial enzymes have gained interest for their widespread uses in industries and medicine owing to their stability, catalytic activity, and ease of production and optimization than plant and animal enzymes (Singh et al., 2016). Microbial aminopeptidases (amino-a

• The number of times an animal reared was the

  2023-10-30

  

  The number of times an animal reared was the only emotional behavior that was significantly higher in the young mice than in the middle-aged group. This may be explained by diminished curiosity or augmented ambulation with aging (Lalonde and Strazielle, 2008). A recent study showed that middle-aged

• Since the first studies of betaine aldehyde oxidation

  2023-10-30

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other 2-deoxy-d-glucose as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of at

• br Translational Considerations Targeting the AHR Pathway

  2023-10-30

  

  Translational Considerations Targeting the AHR Pathway Modulating AHR function offers exciting therapeutic potential in host immunity and inflammation. However, the emerging concept of AHR function in a cell type-specific manner, combined with differences between AHR activation in cell culture in

• Here we have used transcriptome analysis of primary neonatal

  2023-10-30

  

  Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona

• Lipotoxicity is the accumulation of excess lipids in non

  2023-10-30

  

  Lipotoxicity is the accumulation of excess lipids in non-adipose tissues that leads to cell dysfunction or cell death. It may play an important role in the pathogenesis of diabetes, and contributes to the rate of progression of CKD [7,8]. Emerging evidence indicates that renal lipid dysregulation is

• The activation of P Rs modulates the activity of

  2023-10-30

  

  The activation of P1Rs modulates the activity of many ion channels and receptors (Sebastião and Ribeiro, 2009) and the recent detection of P1Rs at the postsynaptic level of the adult NMJ (Garcia et al., 2014) makes potentially possible an adenosine-mediated modulation of the nicotinic kx2 synthesis

• The results also showed that the

  2023-10-30

  

  The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 Fosaprepitant stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection model

• br Funding br Ethics br Conflict

  2023-10-30

  

  Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological acetylcholine receptor of excessive extracellular matrix (ECM) of the liver, as the commo

• br Introduction The process of mitosis is highly complex and

  2023-10-30

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Sorafenib receptor resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in reg

• neurokinin 1 receptor br Introduction Sustained over activat

  2023-10-27

  

  Introduction Sustained over-activation of neurohormonal systems is a hallmark in the pathophysiology of cardiac dysfunction following myocardial infarction (MI) and heart failure (HF). Inhibitors of the renin-angiotensin neurokinin 1 receptor system (RAAS) constitute cornerstones of pharmacothera

• A large number of aldose reductase inhibitors

  2023-10-27

  

  A large number of aldose reductase inhibitors have been prepared synthetically, and a limited number of them are therapeutically used. However, none of them is satisfactory. Here, Cannabis extracts with high content of non-psychotropic phytocannabinoids CBD/CBDA or CBG/CBGA showed statistically sign

• Our previous work fails to show any maternal

  2023-10-27

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

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