• We subsequently performed immunohistochemistry on sections o

  2024-01-08

  

  We subsequently performed immunohistochemistry on sections obtained from mice at 16 weeks after surgery. Type II collagen expression was detected in all articular cartilage zones, but was weak in the upper zone in the vehicle-treated group. MMP-13 and type X collagen expression were increased in the

• br Funding This work was supported by the National

  2024-01-08

  

  Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl

• EPSP analogs were retrieved from PubChem database

  2024-01-08

  

  EPSP analogs were retrieved from PubChem database and docking procedure yielded about eight best binding analogs (Fig. 10). The selected molecules were further assessed for their theoretical Ki values using AUTODOCK software version 4. The predicted binding efficiency of retrieved analogs was estima

• br Materials and methods br Results br Discussion Wound

  2024-01-05

  

  Materials and methods Results Discussion Wound healing of the human cornea is a complex process that requires cell migration and proliferation. Corneal wound healing is characterized by major changes in the composition of the ECM such as a massive transitory secretion of fibronectin combine

• Suramin hexasodium salt A high throughput small molecule ACK

  2024-01-05

  

  A high-throughput small molecule ACK1 biochemical inhibition screen was performed in-house and led to the identification of 1μM inhibitor furanopyrimidine (). Further binding studies found Suramin hexasodium salt to be both ATP-competitive and reversible. Early structure-activity relationship (SA

• 8-CPT-Cyclic AMP sodium salt Using constant potential ampero

  2024-01-05

  

  Using constant potential amperometry and electrochemical enzyme-based biosensors selective for choline—and, therefore, an accurate readout of 8-CPT-Cyclic AMP sodium salt release (Baker et al., 2015; Bruno et al., 2006a; Parikh et al., 2004, 2007)—tonic and phasic release of acetylcholine were meas

• The activity of an enzyme may be

  2024-01-05

  

  The activity of an enzyme may be regulated allosterically as well as transcriptionally. We have consistently studied REMS deprivation (REMSD) associated NA mediated allosteric regulation of Na-K ATPase activity in neurons and glia in vivo and in vitro (Amar and Mallick, 2015; Amar et al., 2016; Bask

• Previously using a P lacZ reporter gene

  2024-01-05

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase pexidartinib australia when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on the expre

• The ambiguity surrounding the role played by the LOXs in

  2024-01-05

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• br Experimental protocols br Results and discussion br

  2024-01-05

  

  Experimental protocols Results and discussion Conclusion 15-LOX-1 is an important mammalian lipoxygenase which plays an important role in the biosynthesis of leukotrienes, lipoxins and other signalling molecules. These signalling molecules play a regulatory role in several respiratory disea

• The compounds containing beryllium act as strong Lewis

  2024-01-05

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be Isochlorogenic acid A synthesis []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extreme

• Disodium (R)-2-Hydroxyglutarate In conclusion the partial se

  2024-01-05

  

  In conclusion, the partial sequencing and characterization of R. quelen cyp19a1b provides essential information about this gene and its presence in peripheral tissues outside of the central nervous system in a teleost. Furthermore, we covered sex differences in the effects of E2 on the cyp19a1b gene

• In previous years evidence emerged that inferred secondary

  2024-01-05

  

  In previous years, evidence emerged that inferred secondary metabolites in plants might exhibit a potential arginase inhibition [36]. In a recent study, Pham and co-workers showed the inhibitory activity of chlorogenic Fenretinide (7) and piceatannol (8) (Fig. 3b) on mammalian arginase with IC50s o

• Protein arrays provide a new approach

  2024-01-04

  

  Protein arrays provide a new approach for the identification of substrates for several protein-modifying enzymes. For example, protein kinase substrate identification, which constitutes an important aspect of pathway mapping because of the prevalence of these substrates in biological pathways. MacBe

• While we chose to divide

  2024-01-04

  

  While we chose to divide our etiologies into three categories, it should be noted that such division has certain limitations. Even though URIs and the common cold are considered mainly viral in origin and rhinosinusitis mainly bacterial in origin,26, 27 there is considerable overlap between these co

14331 records 202/956 page Previous Next First page 上5页 201202203204205 下5页 Last page