• gemcitabine for bladder cancer The observation that vortioxe

  2025-02-20

  

  The observation that vortioxetine blocks 5-HT-induced currents in 5-HT3 receptor-expressing oocytes suggests that vortioxetine acts to functionally antagonize these receptors, and is in line with previously published data (Bang-Andersen et al., 2011). For example, Mørk et al. (2012) demonstrated tha

• Unlike AK inhibition the inhibition of ADA

  2025-02-20

  

  Unlike AK inhibition, the inhibition of ADA activities by EHNA had little effect on spinal reflex potentials, although EHNA did increase extracellular adenosine levels. One explanation for this discrepancy is that the adenosine increase seen herein was not sufficient to inhibit reflex potentials. In

• br Methods br Transparency document br Introduction

  2025-02-20

  

  Methods Transparency document Introduction Epinephrine (EP) is a critical hormone and catecholamine neurotransmitter in nervous system of mammals.1, 2, 3 It has been known to accelerate and regulate heartbeat, blood pressure, bronchodilation, mydriasis, blood sugar and lipolysis, and can he

• Despite functional studies demonstrating the role of

  2025-02-20

  

  Despite functional studies demonstrating the role of 5-HT in ureteral contractility, the source of endogenous 5-HT in the ureter is unclear. Since 5-HT-containing enterochromaffin cells, which are present in the gastrointestinal tract, could not be found in the ureter (Nocito et al., 2007, Ripoche,

• To identify the kinase s mediating H S phosphorylation

  2025-02-20

  

  To identify the kinase(s) mediating H3.3S31 phosphorylation, we devised a 96-well-plate-compatible immunostaining assay, with 98 9 specific for H3.3S31ph, and utilized it to screen both a Qiagen siRNA library covering 720 human kinases and a kinase inhibitor library (Selleck) containing 194 compoun

• br Activity and expression of aromatase in the hippocampus

  2025-02-19

  

  Activity and expression of aromatase in the hippocampus The brain, like the adrenals, gonads and the placenta, is a steroidogenic organ. This paradigm emerged from studies carried out as early as the 1980s by Baulieu and co-workers; these studies showed that steroids such as pregnenolone and dehy

• br Materials and methods br Results br

  2025-02-19

  

  Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include selective p300 inhibitor proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collapse

• br Introduction Heart failure HF is

  2025-02-19

  

  Introduction Heart failure (HF) is a chronically progressive disease and one of the most important causes of morbidity and mortality worldwide despite recent improvements in its treatment [1], [2], [3]. The mortality and morbidity benefits of angiotensin converting enzyme inhibitor (ACEI) are wel

• Pregnane X receptor PXR is a nuclear receptor that

  2025-02-19

  

  Pregnane X receptor (PXR) is a nuclear receptor that plays an important role in regulation of metabolism and disposition of structurally diverse xenobiotics as well as endogenous steroids and bile acids (Bertilsson et al., 1998, Kliewer et al., 1998, Lehmann et al., 1998). PXR regulates the metaboli

• Exposure to B a P is

  2025-02-19

  

  Exposure to B[a]P is an epidemiologically proven cause of lung cancer (Hecht, 2003; Rojas et al., 2004; Alexandrov et al., 2010), and the formation of B[a]PDE-N2-dG adducts is considered to be the critical event in lung tumorigenesis by B[a]P. On the other hand, there is evidence suggesting that the

• habs Adenosine is a ubiquitous homeostatic purine

  2025-02-19

  

  Adenosine is a ubiquitous homeostatic purine nucleoside that accumulates extracellularly in response to metabolic stresses such as hypoxia and inflammation. Activation of either G protein-coupled adenosine receptors (ARs; A1R, A2AR, A2BR, and A3R) by extracellular adenosine can modulate cell signali

• br Results and discussion The classical radiochemical adenos

  2025-02-19

  

  Results and discussion The classical radiochemical adenosine kinase assays developed to monitor AdK activity utilize [3H]adenosine or [14C]adenosine, respectively. The assays are terminated by spotting the incubation mixture onto diethylaminoethyl (DEAE) anion exchange filter disks or onto a poly

• Interestingly a homolog of C elegans acr is

  2025-02-18

  

  Interestingly, a homolog of C. elegans acr-23 is present in the A. suum Hepatocellular carcinoma therapy (Jex et al., 2011). However, A. suum is not susceptible to monepantel treatment in vivo (Tritten et al., 2011). Our research seeks to advance knowledge on the mode of action of monepantel on nAC

• The purpose of this study is to examine the relationship

  2025-02-18

  

  The purpose of this Cy5.5 hydrazide australia study is to examine the relationship between ACEs and engagement in treatment among a sample of youth in residential treatment centers (RTCs). It is hypothesized that youth with higher ACE scores will have lower levels of engagement in treatment. In ord

• Erteberel Several tertiary prevention studies are currently

  2025-02-18

  

  Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut

14494 records 17/967 page Previous Next First page 上5页 1617181920 下5页 Last page